1. Y. Goto*, T. Yamazaki, Y. Ishizuka, H. Ise, Interactions of N-acetyl-D-glucosamine-conjugated silk fibroin with lectins, cytoskeletal proteins and cardiomyocytes, Colloids and Surfaces B: Biointerfaces, , 111406, 2021.
  2. Song I, Ise H*, Development of a Gene Delivery System of Oligonucleotides for Fibroses by Targeting Cell-Surface Vimentin-Expressing Cells with N-Acetylglucosamine-Bearing Polymer-Conjugated Polyethyleneimine, Polymers, 12, 1508, 2020.
  3. Hwang B, Ise H*, Multimeric conformation of type III intermediate filaments but not the filamentous conformation exhibits high affinity to lipid bilayers, Gene to Cells, , published on line, 2020.
  4. Ise H*, Matsunaga K, Shinohara M, Sakai Y, Improved Isolation of Mesenchymal Stem Cells Based on Interactions between N-Acetylglucosamine-Bearing Polymers and Cell-Surface Vimentin, Stem Cells Internatl., , published on line, 2019.
  5. Ise H*, Vimentin’s N-Acetylglucosamine-Binding Activity: Its Physiological Functions, Trends Glycosci. Glycotechnol., 29, E71-E79, 2017.
  6. Ise H*, Yamasaki S, Sueyoshi K, Miura Y, Elucidation of GlcNAc-binding properties of type III intermediate filament proteins, using GlcNAc-bearing polymers, Genes to Cells, 22, 900-917, 2017.
  7. Kim SJ, Ise H*, Kim E, Goto M, Akaike T., Chung BH, Imaging and theapy of liver fibrosis using bioreducible polyethylenimine/siRNA complexes conjugated with N-acetylglucosamine as a targeting moiety, Biomaterials, 34, 6504-6514, 2013.
  8. Komura K, Ise H*, Akaike T. Dynamic behaviors of vimentin induced by interaction with GlcNAc molecules,Glycobiology, 22,1741-1759, 2012.
  9. Yu M, Du F, Ise H, Zhao W, Zhang Y, Yu Y, Yao F, Yang J, Akaike T. Preparation and characterization of a VEGF-Fc fusion protein matrix for enhancing HUVEC growth, Biotechnol. Lett. , 34, 1765-1771, 2012.
  10. Ise H*, Goto M, Komura K, Akaike T. Engulfment and clearance of apoptotic cells based on a GlcNAc-binding lectin-like property of surface vimentin, Glycobiology. , 22, 788-805, 2012.
  11. Kim SJ, Ise H*, Goto M, Akaike T. Interactions of vimentin- or desmin-expressing liver cells with N-acetylglucosamine-bearing polymers, Biomaterials. , 33, 2154-2164, 2012.
  12. Minato A, Ise H*, Goto M, Akaike T. Cardiac differentiation of embryonic stem cells by substrate immobilization of insulin-like growth factor binding protein 4 with elastin-like polypeptides, Biomaterials. , 33, 515-523, 2012.
  13. Ise M, Ise H*, Shiba Y, Kobayashi S, Goto M, Takahashi M, Akaike T, Ikeda U. Targeting N-acetylglucosamine-bearing polymer-coated liposomes to vascular smooth muscle cells, J Artif Organs. , 14, 301-309, 2011.
  14. Kim SJ, Ise H*, Goto M, Komura K, Cho CS, Akaike T. Gene delivery system based on highly specific recognition of surface-vimentin with N-acetylglucosamine immobilized polyethylenimine, Biomaterials. , 32, 3471-3480, 2011.
  15. Ise H*, Kobayashi S, Goto M, Sato T, Kawakubo M, Takahashi M, Ikeda U, Akaike T. Vimentin and desmin possess GlcNAc-binding lectin-like properties on cell surfaces, Glycobiology. , 20, 843-864, 2010.
  16. Kobayashi S, Ise H*, Takahashi M, Goto M, Akaike T, Ikeda U. Surface coating of bone marrow cells with N-acetylglucosamine for bone marrow implantation therapy. Kobayashi S, Biomaterials. , 30, 574-582, 2009.
  17. Misawa R, Soeda J, Ise H, Takahashi M, Kubota K, Mita A, Nakata T, Miyagawa S. Potential feasibility of early bone marrow cell injection into the spleen for creating functional hepatocytes, Transplantation. , 87, 1147-1154, 2009.
  18. Shiba Y, Takahashi M, Hata T, Murayama H, Morimoto H, Ise H, Nagasawa T, Ikeda U. Bone marrow CXCR4 induction by cultivation enhances therapeutic angiogenesis, Cardiovasc Res. , 81, 169-177, 2009.
  19. Murayama H, Takahashi M, Takamoto M, Shiba Y, Ise H, Koyama J, Tagawa Y, Iwakura Y, Ikeda U. Deficiency of tumour necrosis factor-alpha and interferon-gamma in bone marrow cells synergistically inhibits neointimal formation following vascular injury, Cardiovasc Res. , 81, 169-177, 2009.
  20. Yajima N, Takahashi M, Morimoto H, Shiba Y, Takahashi Y, Masumoto J, Ise H, J Sagara, Nakayama J, Taniguchi S, Ikeda U. Critical role of bone marrow-derived ASC, an inflammasome adaptor molecule, in neointimal formation after vascular injury in mice. Circulation, Circulation. , 117, 3079-3087, 2008.
  21. Morimoto H, Hirose M, Takahashi M, Kawaguchi M, Ise H, Kolattukudy PE, Yamada M, Ikeda U. MCP-1 induces cardioprotection against ischemia/reperfusion injury: Role of reactive oxygen species, Cardiovasc Res. , 78, 554-562, 2008.
  22. Nagaoka M, Ise H, Harada I, Koshimizu U, Maruyama A, Akaike T. Embryonic undifferentiated cells show scattering activity on a surface coated with immobilized E-cadherin, J Cell Biochem. , 103, 296-310, 2008.
  23. Kubota K, Soeda J, Misawa R, Mihara M, Miwa S, Ise H, Takahashi M, Miyagawa S. Bone Marrow-derived Cells Fuse with Hepatic Oval Cells but are not involved in Hepatic Tumorigenesis in the Choline-deficient Ethionine-supplemented Diet Rat Model, Carcinogenesis. , 29, 448-454, 2008.
  24. Tanabe T, Fujimoto K, Yasuo M, Tsushima K, Yoshida K, Ise H, Yamaya M. Modulation of mucus production by interleukin-13 receptor alpha in the human airway epithelium, Clin Exp Allergy. , 38, 122-134, 2008.
  25. Aso S, Ise H*, Takahashi M, Kobayashi S, Morimoto H, Izawa A, Goto M, Ikeda U. Effective uptake of N-acetylglucosamine-conjugated liposomes by cardiomyocytes in vitro, J. Control Release. , 122, 189-198, 2007.
  26. Ogawa R, Takahashi M, Hirose S, Morimoto H, Ise H, Murakami T, Yasue T, Kuriyama K, Hongo M, Kobayashi E, Ikeda U. A novel sphingosine-1-phosphate receptor agonist KRP-203 attenuates rat autoimmune myocarditis, Biochem Biophys Res Commun. , 361, 621-628, 2007.
  27. Morimoto H, Takahashi M, Shiba Y, Izawa A, Ise H, Hongo M, Hatake K, Motoyoshi K, Ikeda U. Bone marrow-derived CXCR4+ cells mobilized by macrophage colony-stimulating factor participate in the reduction of infarct area and improvement of cardiac remodeling after myocardial infarction in mice, Am J Pathol. , 171, 755-766, 2007.
  28. Hirose S, Takahashi M, Ogawa R, Morimoto H, Izawa A, Sato H, Ise H, Hongo M, Ikeda U. Erythropoietin attenuates the development of experimental autoimmune myocarditis, Cardiovasc Drugs Ther. , 21, 17-27, 2007.
  29. Shiba Y, Takahashi M, Yoshioka T, Yajima N, Morimoto H, Izawa A, Ise H, Hatake K, Motoyoshi K, Ikeda U. M-CSF accelerates neointimal formation in the early phase after vascular injury in mice: the critical role of the SDF-1-CXCR4 system, Arterioscler Thromb Vasc Biol. , 27, 283-289, 2007.
  30. Misawa R, Ise H*, Takahashi M, Morimoto H, Kobayashi E, Miyagawa S, Ikeda U. Development of liver regenerative therapy using glycoside-modified bone marrow cells, Biochem Biophys Res Commun. , 342, 434-440, 2006.
  31. Morimoto H, Takahashi M, Izawa A, Ise H, Hongo M, Kolattukudy PE, Ikeda U. Cardiac overexpression of monocyte chemoattractant protein-1 in transgenic mice prevents cardiac dysfunction and remodeling after myocardial infarction, Circ Res. , 99, 891-899, 2006.
  32. Suzuki C, Takahashi M, Morimoto H, Izawa A, Ise H, Hongo M, Hoshikawa Y, Ito T, Miyashita H, Kobayashi E, Shimada K, Ikeda U. Mycophenolate mofetil attenuates pulmonary arterial hypertension in rats, Biochem Biophys Res Commun. , 349, 781-788, 2006.
  33. Matsunaga T, Kose E, Yasuda S, Ise H, Ikeda U. Determination of p-glycoprotein ATPase activity using luciferase. Ohmori S, Biol Pharm Bull. , 29, 560-564, 2006.
  34. Suzuki C, Takahashi M, Morimoto H, Izawa A, Ise H, Fujishiro J, Murakami T, Ishiyama J, Nakada A, Nakayama J, Shimada K, Ikeda U, Kobayashi E. Efficacy of mycophenolic acid combined with KRP-203, a novel immunomodulator, in a rat heart transplantation model, J Heart Lung Transplant. , 25, 302-329, 2006.
  35. Sato H, Takahashi M, Ise H, Yamada A, Hirose S, Tagawa Y, Morimoto H, Izawa A, Ikeda U. Collagen synthesis is required for ascorbic acid-enhanced differentiation of mouse embryonic stem cells into cardiomyocytes, Biochem Biophys Res Commun. , 342, 107-112, 2006.
  36. Jia L, Takahashi M, Yoshioka T, Morimoto H, Ise H, Ikeda U. Therapeutic potential of endothelial progenitor cells for cardiovascular diseases, Curr Vasc Pharmacol. , 4, 59-65, 2006.
  37. Yoshioka T, Takahashi M, Shiba Y, Suzuki C, Morimoto H, Izawa A, Ise H, Ikeda U. Granulocyte colony-stimulating factor (G-CSF) accelerates reendothelialization and reduces neointimal formation after vascular injury in mice, Cardiovasc Res. , 70, 61-69, 2006.
  38. Jia L, Takahashi M, Morimoto H, Takahashi S, Izawa A, Ise H, Iwasaki T, Hattori H, Wu KJ, Ikeda U. Changes in cardiac lipid metabolism during sepsis: the essential role of very low-density lipoprotein receptors, Curr Vasc Pharmacol. , 4, 59-65, 2006.
  39. Suzuki F, Hashikura Y, Ise H, Ishida A, Nakayama J, Takahashi M, Miyagawa S, Ikeda U. MCI-186 (edaravone), a free radical scavenger, attenuates hepatic warm ischemia-reperfusion injury in rats, Transpl Int. , 18, 844-853, 2005.
  40. Takahashi M, Takahashi S, Suzuki C, Jia L, Morimoto H, Ise H, Iwasaki T, Hattori H, Suzuki J, Miyamori I, Kobayashi E, Ikeda U. Interleukin-1beta attenuates beta-very low-density lipoprotein uptake and its receptor expression in vascular smooth muscle cells, J Mol Cell Cardiol. , 38, 637-646, 2005.
  41. Zhao P, Ise H, Hongo M, Ota M, Konishi I, Nikaido T. Human amniotic mesenchymal cells have some characteristics of cardiomyocytes, Transplantation. , 79, 528-535, 2005.
  42. Ise H*, Nikaido T, Negishi N, Sugihara N, Suzuki F, Akaike T, Ikeda U. Effective hepatocyte transplantation using rat hepatocytes with low asialoglycoprotein receptor expression, Am. J. Pathol. , 165, 501-510, 2004.
  43. Takashima S, Ise H, Zhao P, Akaike T, Nikaido T. Human amniotic epithelial cells possess hepatocyte-like characteristics and functions, Cell Struct Funct. , 29, 73-84, 2004.
  44. Matsunaga T, Maruyama M, Harada E, Katsuyama Y, Sugihara N, Ise H, Negishi N, Ikeda U. Expression and induction of CYP3As in human fetal hepatocytes, Biochem Biophys Res Commun. , 318, 428-434, 2004.
  45. Kobayashi M, Sugihara N, Ise H, Omasa T, Negishi N. Real time monitoriing of drug metabolic enzyme response inside human hepatoma GS-3A4-HepG2 cells by means of electrochemical impedance measurement, Polymers for Advanced Technologies. , 15, 232-243, 2004.
  46. Nonaka H, Ise H, Sugihara N, Hirose S, Negishi N, Kondo Y, Akaike T. Development of Highly Functional Long-Term Culture Method of Liver Slice Embeded in Polymer Scaffold for Bioartificial Liver, Cell Transplantation. , 12, 491-498, 2003.
  47. Nagaoka M, Ise H, and Akaike T. Immobilized E-cadherin model can enhance cell attachment and differentiation of primary hepatocytes but not proliferation, Biotechnology Letters. , 24, 1857-1862, 2002.
  48. Sugihara N, Ise H, Negishi N, Nikaido T, and Akaike T. Drug metabolic activity of cultured hepatocytes can synchronize with bile acid concentration in the medium, Cell Biochem. Funct. , 20, 11-17, 2002.
  49. Kakegawa T, Ise H, Sugihara N, Nikaido T, Negishi N, Akaike T and Tanaka E. Soluble Asialoglycoprotein Receptors Reflect the Apoptosis of Hepatocytes. Cell Transplantation, Cell Transplantation. , 11, 407-415, 2002)
  50. Yang J, Goto M, Ise H, Cho CS and Akaike T. Galactosylated alginate as a scaffold for hepatocytes entrapment, Biomaterials. , 23, 471-479, 2002.
  51. Ise H, Sugihara N, Negishi N, Nikaido T and Akaike T. Low Asialoglycoprotein Receptor Expression as Markers for Highly Proliferative Potential Hepatocytes, Biochem. Biophys. Res. Commun. , 285, 172-182, 2001.
  52. Ise H, Ferdous A, Sugihara N, Nikaido T, Negishi N and Akaike T. Separation of Mouse Hepatocytes of Distinct Biological Phenotypes Based on Their Asialoglycoprotein Receptor-mediated Binding Affinity to an Artificial Ligand, Journal of Artificial Organs. , 4, 342-347, 2001.
  53. Hirose S, Ise H, Uchiyama M, Cho CS and Akaike T. Regulation of Asialoglycoprotein Receptor Expression in the Proliferative State of Hepatocytes, Biochem. Biophys. Res. Commun. , 287, 675-681, 2001.
  54. Uchida T, Serizawa T, Ise H, Akaike T and Akashi M. Graft Copolymer Having Hydrophobic Backbone and Hydrophilic Branches. 34. Interaction of Hepatocytes and Polystyrene Nanospheres Having Lactose-Immobilized Hydrophilic Polymers on Their Surfaces, Biomacromolecules. , 2, 1343-1346, 2001.
  55. Ise H, Takashima S, Nagaoka M, Ferdous A and Akaike T. Analysis of cell viability and differential activity of mouse hepatocytes under 3D and 2D culture in agarose gel, Biotechnology Letters. , 21, 209-213, 1999.
  56. Cho CS, Nah JW, Jeong YI, Cheon JB, Asayama S, Ise H, Akaike T. Coformational transition of nanoparticles composed of poly(g-benzyl L-glutamate) as the core and poly(ethylene oxide) as the shell, Polymer. , 40, 6769-6775, 1999.
  57. Ise H, Maruyama A, Ebara Y, Okahata Y, and Akaike T. Extracellular Matrix for Liver Tissue Engineering. Takei R, Park KH, TISSUE ENGINEERING. , 3, 281-288, 1997.
  58. Hori H, Noguchi N, Yokoyama H, Ise H, Jin CZ, Kasai S, Goto T, and Taira Z. Design and synthesis of new mitochondrial cytotoxin N-thiadiazolylanilines that inhibit tumor cell growth, Bioorg Med Chem. , 4, 247-253, 1996.


  • 九州大学
  • 九州大学 先導物質科学研究所
  • 九州大学 工学研究院応用科学部門分子教室
  • 九州大学 伊都新キャンパス